Method of preparing .delta.5,7-steroids

Details Method of preparing .delta.5,7-steroids Method of preparing .delta.5,7-steroids

C - Chemistry, Metallurgy

07

J

260/7.5

C07J 1/00 (2006.01) C07J 9/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 1192184

ABSTRACT: The invention relates to a method of preparing .DELTA. 5,7-steroids, in particular 7-dehydrocholesterol compounds, of the general formula Image wherein R is a hydrogen atom, a hydroxy group, optionally etheri- fied with a C1-C4 alkanol or esterified with a C1-C4 alkane carboxylic acid, a C2-C5 alkanoyl group, optio- nally ketalized with a C1-C4 alkanol, or a branched or non-branched, saturated or unsaturated C1-C10 alkyl group, optionally substituted with one or more fluorine atoms or hydroxy groups, which hydroxygroup or groups is (are) optionally etherified with C1-C4 alkanol(s) or esterified with C1-C4 alkane carboxylic acid(s), and R1, R2 and R3 are equal or different and represent hydro- gen atoms or hydroxy groups, optionally etherified with C1-C4 alkanols or esterified with C1-C4 alkane carboxy- lic acids, or wherein R1 and R2 together constitute a C2-C4 alkylene dioxy group, by dehydrobrominating 7-bromo-.DELTA.5-steroids under the influence of a fluoride as a base in an organic solvent.

419223

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