Method of preparing highly purified alpha-1-proteinage...

Details Method of preparing highly purified alpha-1-proteinage... Method of preparing highly purified alpha-1-proteinage...

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C07K 1/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340236

There is disclosed a highly purified concentrate of alpha-1-proteinase inhibitor. A method of removing proteins having disulfide bonds, with mild reducing agents and a temperature sufficient to prohibit regrouping of the reduced proteins, results in essentially pure alpha-1-proteinase inhibitor. This method can be combined with a heat inactivation process.

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