B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
117/45.2
B01J 13/02 (2006.01) A61K 9/16 (2006.01) A61K 9/62 (2006.01) B01J 13/12 (2006.01)
Patent
CA 1220098
ABSTRACT OF THE DISCLOSURE The method of preparing microspheres containing therapeutic or diagnostic agents, is disclosed which comprises: (a) preparing a solution by dissolving the agent and a non-toxic matrix material in a first organic solvent in which they are mutually soluble, the matrix material being heat-liquifiable and having a congealing temperature above 100°F, the first organic solvent having a dielectric constant above 15; (b) dispersing the prepared solution in a second organic solvent to form an emulsion containing dispersed droplets of the solution in the second solvent as the continuous phase, the second organic solvent having a dielectric constant below 5, and being present in at least as great a volume as the solution; (c) removing substantially all of the both of the solvents from the dispersion while maintaining the droplets at a temperature substantially below the congealing temperature of the matrix material to produce solid microspheres comprising the matrix material with the water-soluble agent distributed therein; and (d) recovering the microspheres.
467834
Borden Ladner Gervais Llp
Mosier Benjamin
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