Method of preparing new derivatives of d, l-tyrosine having...

Details Method of preparing new derivatives of d, l-tyrosine having... Method of preparing new derivatives of d, l-tyrosine having...

C - Chemistry, Metallurgy

07

D

260/325, 260/389

C07D 295/14 (2006.01) C07D 295/092 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01)

Patent

CA 1048503

ABSTRACT Method of preparing new derivatives of D,L - tyrosine of the formula: Image comprising di-acylating D,L-tyrosine, amidating the carboxyl group of the diacyl derivative to obtain an amidoester, hydrolyzing the amidoester thereby obtaining its corresponding diamido-derivative, and etherifying the latter. In the above formula R1 is a linear or branched chain alkyl radical having 1 to 6 carbons and terminating in a tertiary amino group; R2 is a phenyl group which may be substituted by chlorine, bromine nitro, methoxy or methyl; and R3 is a secondary or tertiary amino group. The new derivatives of D,L-tyrosine have antispastic activity in animals.

219028

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