C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/325, 260/389
C07D 295/14 (2006.01) C07D 295/092 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01)
Patent
CA 1048503
ABSTRACT Method of preparing new derivatives of D,L - tyrosine of the formula: Image comprising di-acylating D,L-tyrosine, amidating the carboxyl group of the diacyl derivative to obtain an amidoester, hydrolyzing the amidoester thereby obtaining its corresponding diamido-derivative, and etherifying the latter. In the above formula R1 is a linear or branched chain alkyl radical having 1 to 6 carbons and terminating in a tertiary amino group; R2 is a phenyl group which may be substituted by chlorine, bromine nitro, methoxy or methyl; and R3 is a secondary or tertiary amino group. The new derivatives of D,L-tyrosine have antispastic activity in animals.
219028
Makovec Francesco
Rovati Luigi
Senin Paolo
Na
Rotta Research Laboratorium S.p.a.
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