C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01)
Patent
CA 2438854
The invention relates to non-hydrated fexofenadine hydrochloride which can be obtained from a fexofenadine base and hydrogen chloride, according to the reaction conditions, either in the form of a novel polymorph ("form A"), in an amorphous form, or in the form of a mixture of different polymorphs. Said novel polymorph ("form A") can be used as a therapeutic active ingredient and can be processed to form a pharmaceutical containing the same and a pharmaceutically acceptable carrier. Said pharmaceutical is suitable for use as an antihistaminic agent, an antiallergic agent and/or a bronchodilating agent.
L'invention concerne de l'hydrochlorure fexifenadine non hydraté, qui est obtenu à partir de la base fexofenadine et de gaz chlorhydrique, selon les conditions de réaction, soit sous forme d'un nouveau polymorphe ("forme A"), soit sous forme amorphe, soit sous forme de mélange de plusieurs polymorphes différents. Ce nouveau polymorphe ("forme A") sert de substance thérapeutique, qui peut être transformée en médicament la contenant avec un excipient pharmaceutiquement acceptable. Ce médicament est utile en tant qu'antihistaminique, antiallergique et/ou broncho-dilatateur.
Blake Cassels & Graydon Llp
Cilag Ag
LandOfFree
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