Method of preparing organ for transplantation

Details Method of preparing organ for transplantation Method of preparing organ for transplantation

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61L 27/38 (2006.01) C12N 5/071 (2010.01) C12N 5/0775 (2010.01)

Patent

CA 2606983

To provide a means for achieving generation of complex organ such as kidney by a method of generating a human organ using hMSCs. In a method of preparing a desired organ for transplantation in human by inducing differentiation of a human mesenchymal stem cell by transplanting the fractionated human mesenchymal stem cell to an embryo of a pregnant mammal host, the method of preparing an organ for transplantation is characterized in that the transplantation site of the human mesenchymal stem cell in the embryo is a site corresponding to the differentiation site of the desired organ in the host and the transplantation time of human derived organ for transplantation is in a stage when the immune system of the host is still in an immune tolerance stage.

La présente invention concerne des moyens pour réussir la production d~un organe complexe tel qu~un rein par un procédé de production d~un organe humain en utilisant des souches hMSC. Dans un procédé de préparation d~un organe souhaité à transplanter dans un être humain par le déclenchement d~une différentiation d~une cellule souche mésenchymateuse humaine par transplantation de la cellule souche mésenchymateuse humaine fractionnée dans un embryon d~un mammifère gravide hôte, le procédé de préparation d~un organe à transplanter est caractérisé en ce que le site de transplantation de la cellule souche mésenchymateuse humaine dans l~embryon est un site correspondant au site de différentiation de l~organe souhaité chez l~hôte et le moment de transplantation d~un organe dérivé d~humain à transplanter est à un stade où le système immunitaire est toujours à un stade de tolérance immunitaire.

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