Method of preparing particles for agglomeration

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/167 (2006.01) A61K 31/58 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2360649

Methods of preparing particulates for agglomeration, having a specified particle size distribution and desired convertible amorphous content, are described. The method involves a plurality of micronizing steps at least two of which are separated by a curing step. In the curing step, a stimulus such as humidity may be used to crystallize at least some, and in many instances preferably all, of the convertible amorphous content.

L'invention porte sur des procédés de préparation de matières particulaires pour l'agglomération qui ont une granulométrie spécifique et un contenu amorphe convertible désiré. Ce procédé comprend plusieurs étapes de micronisation dont au moins deux sont séparées par une étape de durcissement. Dans l'étape de durcissement, un stimulus tel que l'humidité peut être utilisé pour cristalliser au moins une partie du contenu amorphe convertible, et dans certains cas, la totalité.

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