Method of preparing pyridazinone derivatives

Details Method of preparing pyridazinone derivatives Method of preparing pyridazinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 237/10 (2006.01) A01N 43/58 (2006.01) C07D 237/24 (2006.01)

Patent

CA 2065333

A method for the preparation of a pyridazinone derivative having general formula (I), where: R1 is a phenyl group, optionally substituted, R2 is H, alkyl or carboxy, R3 is H, alkyl or alkoxy and R4 is alkyl; said method comprising reacting a hydrazone of glyoxylic acid halide having formula (VII) in which X is halogen, with an ester of formula (VIII) in the presence of an alkaline earth base.

Procédé de préparation d'un dérivé de pyridazinone ayant la formule générale (I), dans laquelle: R1 représente un groupe phényle, facultativement substitué, R2 représente H, alkyle ou carboxy, R3 représente H, alkyle ou alcoxy et R4 représente alkyle; ledit procédé consistant à faire réagir une hydrazone d'halogénure d'acide glyoxylique ayant la formule (VII), dans laquelle X représente halogène, avec un ester de la formule (VIII) en présence d'une base alcalino-terreuse.

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