A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/28 (2006.01) A61K 9/36 (2006.01)
Patent
CA 2488860
A method of preparing a coated solid dosage form is disclosed wherein a solid dosage form, such as a compressed tablet with active agent dispersed therein, is coated at least twice with a coating solution comprising a water-insoluble coating polymer and a water-soluble pore former, and cured after at least the first coating step. The method of the present invention allows for the production of cured coated solid dosage forms using very short curing times. Coated solid dosage forms produced according to the present invention have been found to have long extended release characteristics.
L'invention concerne un procédé de préparation d'une forme de dosage solide enrobée dans lequel une forme de dosage solide, telle qu'un comprimé contenant un principe actif dispersé, est enrobée au moins deux fois au moyen d'une solution d'enrobage comprenant un polymère d'enrobage insoluble dans l'eau et un façonneur de pore hydrosoluble, et durcie au moins après la première étape d'enrobage. Le procédé de cette invention permet de produire des formes de dosage solides enrobées avec des temps de durcissement très courts. Les formes de dosage solides enrobées produites ainsi possèdent des caractéristiques de libération retardée longues.
Grant David J.w.
Heimlich John M.
Lee Ernest J.
Noack Robert M.
Pharmacia Corporation
Sim & Mcburney
LandOfFree
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