Method of preparing vicinal aminoalcohols

Details Method of preparing vicinal aminoalcohols Method of preparing vicinal aminoalcohols

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) C07C 213/00 (2006.01) C07C 215/08 (2006.01) C07C 215/24 (2006.01) C07C 215/28 (2006.01) C07C 215/34 (2006.01) C07C 217/08 (2006.01) C07C 217/28 (2006.01) C07C 217/70 (2006.01) C07C 255/59 (2006.01) C07C 317/32 (2006.01) C07C 323/32 (2006.01) C07D 307/20 (2006.01) C07D 309/12 (2006.01) C07D 317/58 (2006.01) C07D 319/18 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2088552

DIR 0502 Abstract The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the starting cyanohydrin derivatives. The present invention is also concerned with certain new enantiomerically pure hydroxyl-protected vicinal aminoalcohols.

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