Method of presuming domain linker region of protein

Details Method of presuming domain linker region of protein Method of presuming domain linker region of protein

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 7/08 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) G06F 17/30 (2006.01) G06F 19/00 (2006.01) G06N 3/02 (2006.01) G06N 3/08 (2006.01)

Patent

CA 2462591

A domain linker region is presumed by inputting the amino acid sequence of a protein with an unknown stereostrcture into a hierarchical neural network capable of distinguishing domain linker regions. Sequencial characteristics of a linker domain are clarified by using statistical techniques and the obtained data are combined with a method of presuming the secondary structure. Thus, a method of presuming the domain linker of an amino acid sequence with an unknown structure can be constructed.

Une région de liaison à un domaine est supposée par introduction de la séquence d'acides aminés d'une protéine présentant une stéréostructure inconnue dans un réseau neuronal hiérarchisé capable de distinguer des régions de liaison de domaine. Des caractéristiques séquentielles d'un domaine de liaison sont clarifiées au moyen de techniques statistiques et les données obtenues sont combinées selon un procédé permettant de supposer la structure secondaire. Ainsi, on peut mettre au point un procédé permettant de supposer la liaison de domaine d'une séquence d'acides aminés à l'aide d'une structure inconnue.

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