Method of preventing acute rejection following solid organ...

Details Method of preventing acute rejection following solid organ... Method of preventing acute rejection following solid organ...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266315

The invention provides methods of preventing acute rejection following renal or other solid organ transplantation. The methods entail administering, e.g., intravenously, to a transplant patient a monoclonal antibody which binds to the p55 subunit of the human interleukin-2 (IL-2) receptor of human T lymphocytes. The monoclonal antibody is preferably a chimeric or humanized antibody that blocks binding of IL-2 to the IL-2 receptor. In some methods, a single dose of about 1 mg/kg of antibody is administered about every other week, commencing immediately prior to transplantation and continuing until 8 weeks after transplantation.

Méthodes pour prévenir une crise de rejet suivant la transplantation d'un rein ou d'un autre organe solide. Cette méthode consiste à administrer au patient transplanté, p.ex. par voie intraveineuse, un anticorps monoclonal qui se lie à la sous-unité p55 du récepteur d'interleukine-2 humaine (IL 2) des lymphocytes T humains. L'anticorps monoclonal est de préférence un anticorps chimère ou humanisé qui bloque la liaison de l'IL-2 au récepteur d'IL-2. Dans certaines méthodes, une dose unique d'environ 1 mg/kg d'anticorps est administrée environ une semaine sur deux, en commençant immédiatement avant la transplantation et en continuant environ 8 semaines après la transplantation.

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