Method of preventing adverse effects by glp-1

Details Method of preventing adverse effects by glp-1 Method of preventing adverse effects by glp-1

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/495 (2006.01) A61K 38/26 (2006.01)

Patent

CA 2703338

A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon- like peptide 1(GLP-1 ) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.

La présente invention concerne un procédé destiné à prévenir ou à réduire les effets indésirables, tels que la transpiration abondante, les nausées et les vomissements, normalement associés à l'administration thérapeutique sous-cutanée et intraveineuse du peptide 1 semblable au glucagon (GLP-1). En particulier, ledit procédé comprend l'administration rapide d'une formulation de GLP-1 dans la circulation pulmonaire, par exemple par inhalation, directement dans les capillaires alvéolaires des poumons, au moyen d'un système d'administration de médicament sous forme de poudre sèche.

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