A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/35 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) C07D 311/22 (2006.01)
Patent
CA 2218306
Disclosed is a use of a compound of the formula: (see fig. I) (wherein n is 1-3; A is O, S, CH2, NH or N-alkyl; B is CR4R5 where R4 and R5 are H, alkyl, R6R7-alkyl or R6R7-alkoxy in which R6 and R7 are H, alkyl, cycloalkyl, aryl or heteroaryl or R4 and R5 together with the C atom form cycloalkyl; R1 is tetrazolyl, carboxyl, carboxyalkenyl, alkyl cycloalkyl, etc. and R2 is H, F, Cl, alkyl, alkoxy, etc.), or a pharmaceutically acceptable salt thereof for suppressing the rejection of allogenic transplants in a mammal, including a human.
L'invention porte sur un composé de formule (voir fig. I) (où n est 1-3; A est O, S, CH2, NH ou N-alkyle; B est CR4R5 où R4 et R5 sont H, un groupe alkyle, R6R7-alkyle ou R6R7-alcoxy, R6 et R7 étant H, un groupe alkyle, cycloalkyle, aryle ou hétéroaryle, ou bien R4 et R5 forment avec l'atome de C un cycloalkyle; R1 est un groupe tétrazolyle, carboxyle, carboxyalcényle, alkylcycloalkyle, etc., et R2 est H, F, Cl, un alkyle, un alcoxy, etc.); ou sur un de ses sels acceptables en pharmacie; ces produits sont utiles pour empêcher le rejet de greffes allogéniques chez un mammifère, y compris l'homme.
Showell Henry James
Weringer Elora Jeanne
Limited Pfizer
Smart & Biggar
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