Method of preventing fibrin clots in pulmonary tissue...

Details Method of preventing fibrin clots in pulmonary tissue... Method of preventing fibrin clots in pulmonary tissue...

A - Human Necessities

61

K

A61K 38/55 (2006.01) A61K 31/727 (2006.01) A61K 38/36 (2006.01)

Patent

CA 2557411

ATIII is a serine proteinase inhibitor (serpin) with anti-coagulant, anti- inflammatory, anti-proliferative and anti-angiogenic properties. The invention features methods of treating a subject having lung injury due to bums and smoke inhalation by administering a synergistic combination of antithrombin III and heparin through pulmonary delivery means.

L'ATIII est un inhibiteur de la sérine protéinase (serpin) possédant des propriétés anticoagulantes, anti-inflammatoires, antiprolifératives et anti-angiogéniques. L'invention concerne également des méthodes destinées au traitement d'un sujet atteint d'une lésion pulmonaire suite à des brûlures et à l'inhalation de fumées, consistant à administrer à ce sujet une combinaison synergique d'antithrombine III et d'héparine à l'aide d'un moyen d'administration par voie pulmonaire.

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