Method of preventing nmda receptor-mediated neuronal damage

Details Method of preventing nmda receptor-mediated neuronal damage Method of preventing nmda receptor-mediated neuronal damage

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2143752

Disclosed is a method for reducing non-ischemic NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a compound of the formula shown in Fig. 1 (or a physiologically- acceptable salt thereof), wherein R1 includes an amino group, R2-R17 are independently H or a short chain aliphatic group comprising 1-5 carbons, and R4 and R10 also may (independently) be a halogen or an acyl group. Also disclosed is a screen for antagonists of NMDA receptor mediated neurotoxicity which have an enhanced prospect for being clinically tolerated and selective against such neurotoxicity.

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