Method of preventing or limiting reperfusion damage

Details Method of preventing or limiting reperfusion damage Method of preventing or limiting reperfusion damage

A - Human Necessities

61

K

A61K 31/495 (2006.01) C07D 241/04 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2044143

The use of a N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of an organ or muscular tissue, particularly in a patient undergoing thrombolysis or reperfusion of the heart after open heart surgery or after receiving a donor heart. The use of a N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of a transplanted heart. The use of a N-alkylpiperazinealkanamide for storing a heart for transplantation for at least 24 hours in a cold cardioplegic solution. Compositions comprising an effective reperfusion damage preventing and/or limiting amount of a N-aryl-piperazinealkanamide derivative and optionally further comprising a thrombolytic agent and/or a cyclodextrin or an ether derivative thereof. Processes for preparing such compositions. Novel N-alkylpiperazinealkanamide compounds and a process for preparing said compounds.

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