Method of preventing or treating disease characterized by...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2179196

There is disclosed a method of treating a mammal afflicted with a disease characterized by neoplastic cells that express CD40, comprising administering a therapeutically effective amount of a CD40 binding protein in a pharmaceutically acceptable buffer. CD40 binding proteins include monoclonal antibodies to CD40, and CD40 ligand. CD40 binding proteins may also be used to prevent disease characterized by neoplastic cells that express CD40, in individuals at risk for such disease.

L'invention concerne un procédé de traitement d'un mammifère souffrant d'une maladie se caractérisant par des cellules néoplasiques exprimant le CD40. Ledit traitement consiste à administrer une dose efficace au plan thérapeutique de la protéine fixant le CD40 dans une solution tampon pharmaceutiquement acceptable. Ces protéines de fixation de CD40 comprennent des anticorps monoclonaux dirigés contre le CD40, et un ligand de CD40, et peuvent être utilisées pour prévenir une maladie se caractérisant par des cellules néoplasiques exprimant le CD40 chez les individus sujets à ce type de pathologie.

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