Method of preventing prostatic carcinoma with 17beta...

Details Method of preventing prostatic carcinoma with 17beta... Method of preventing prostatic carcinoma with 17beta...

A - Human Necessities

61

K

A61K 31/58 (2006.01)

Patent

CA 2084798

97/RJN50 - i - 18626 TITLE OF THE INVENTION METHOD OF PREVENTING PROSTATIC CARCINOMA WITH 17.beta.-ACYL 4-AZA-5.alpha.-ANDROST-1-ENE-3-ONES ABSTRACT OF THE INVENTION 17.beta.-Acyl-4-aza-5.alpha.-androst-1-ene-3-ones of the formula: Image I 97/RJN50 - ii - 18626 wherein R is selected from hydrogen, methyl and ethyl and R2 is monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents; and R', R'' and R''' are each selected from hydrogen and methyl and pharmaceutical formulation of the above compounds are active as testosterone 5.alpha.-reductase inhibitors and thus are useful for the prevention of prostatic carcinoma.

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