Method of producing 5-fluorouracil derivatives

Details Method of producing 5-fluorouracil derivatives Method of producing 5-fluorouracil derivatives

C - Chemistry, Metallurgy

07

D

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C07D 239/22 (2006.01) C07D 405/14 (2006.01)

Patent

CA 1122983

ABSTRACT OF THE DISCLOSURE A new and industrially useful method of producing 1(or 1,3-bis)-(tetrahydro-2-furyl)-5-fluorouracil or a mixture thereof by reacting 5-fluorouracil with 2,3-dihydrofuran at elevated temperature in a closed vessel. Depending upon 1,3-Bis-(tetrahydro-2-furyl)-5-fluorouracil thus formed can be converted to 1-(tetrahydro-2-furyl)-5-fluorouracil by solvolysis under non-acidic conditions.

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