Method of producing a blood-coagulation-promoting...

Details Method of producing a blood-coagulation-promoting... Method of producing a blood-coagulation-promoting...

A - Human Necessities

61

K

167/103.34

A61K 35/16 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1079191

ABSTRACT OF THE DISCLOSURE: In a method of producing a blood-coagulation-promoting preparation from human blood plasma, which preparation con- tains a new blood-coagulating substance called "FEIBA", human plasma with citrate ions is treated with water-insoluble inorganic coagulation-physiologically-surface-active substances in the absence of free calcium ions, thus generating "FEIBA", the water-insoluble substances are separated, the supernatant is treated with basic ion exchangers, wherein "FEIBA" and the coagulation factors II-VII-IX-X adhere to the ion exchangers, and "FEIBA" and the factors II-VII-IX-X are eluted and con- centrated.

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