Method of producing a modified (poly)peptide

Details Method of producing a modified (poly)peptide Method of producing a modified (poly)peptide

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01) A61K 38/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2624155

This invention relates to a method of producing a modified (poly)peptide, said method comprising the step of modifying in an organic solvent a crown ether- bound (poly)peptide at one or more carboxylic groups by esterification or thioesterification and/or at the amino group of the N-terminal amino acid by amidation or alkylation. Furthermore provided are (poly)peptides and antibodies obtainable with the method of the invention as well as medical uses thereof.

L'invention concerne un procédé pour produire un (poly)peptide modifié, ce procédé consistant à modifier, dans un solvant organique, un (poly)peptide à liaison éther couronne dans un ou plusieurs groupes carboxyliques par estérification ou thioestérification et/ou dans le groupe amino de l'aminoacide N-terminal par amidation ou alkylation. La présente invention porte également sur des (poly)peptides et des anticorps pouvant être obtenus selon ce procédé, ainsi que sur leurs utilisations médicales.

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