C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) C12Q 1/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2657498
The invention relates to a method of producing a multichimeric mouse comprising a functional xenogenic (human) immune system restricted to the MHC class I and/or class II molecules (HLA molecules) of the xenogenic species solely, and a functional tissue. The invention relates also to the use of the multichimeric mouse obtainable by said method, to study the immunopathogenesis of tissue-specific diseases (infectious, tumoral or auto-immune pathologies) and to their applications to design and test vaccines or immunotherapeutic agents against these pathologies.
La présente invention concerne un procédé de production d'une souris multichimérique comprenant un système immunitaire xénogène (humain) fonctionnel limité aux molécules de la classe I et/ou de la classe II du CMH (molécules HLA) de l'espèce xénogène uniquement, et un tissu fonctionnel. L'invention concerne également l'utilisation de la souris multichimérique qui peut être obtenue par ledit procédé pour étudier l'immunopathogenèse de maladies spécifiques de tissu (pathologies infectieuses, tumorales ou auto-immunitaires) et les applications dans la conception et les essais de vaccins ou d'agents immunothérapeutiques contre ces pathologies.
Garcia Sylvie
Tartour Eric
Centre National de La Recherche Scientifique
Fasken Martineau Dumoulin Llp
Institut Pasteur
Universite Paris Descartes
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