Method of producing a polyether antibiotic from actinomadura...

Details Method of producing a polyether antibiotic from actinomadura... Method of producing a polyether antibiotic from actinomadura...

C - Chemistry, Metallurgy

12

P

C12P 19/02 (2006.01) C07D 493/10 (2006.01) C12P 17/18 (2006.01) C12P 19/60 (2006.01)

Patent

CA 2077837

X-8038 ABSTRACT Improved processes for producing a polyether antibiotic compound represented by A82810 comprising: (1) cultivating Actinomadura fibrosa sp. nov. NRRL 18348 or Actinomadura sp. NRRL 18880, (2) feeding acid hydrolyzed casein at a rate from about 2.50 - 7.50 gm/L/day, (3) feeding glucose at a rate from about 2.50 - 7.50 gm/L/day, and (4) feeding propionate at a rate from about 0.50 - 1.5 gm/L/day to the appropriate culture medium during fermentation, are provided.

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