Method of producing a stable particle -matrix system

Details Method of producing a stable particle -matrix system Method of producing a stable particle -matrix system

B - Operations, Transporting

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31/80.1

B01J 20/22 (2006.01) A61L 26/00 (2006.01) C08J 3/02 (2006.01) C08J 3/03 (2006.01)

Patent

CA 1276447

ABSTRACT OF THE DISCLOSURE A method of stabilizing an aqueous dispersion of water- absorbent particles of organic origin and at least one matrix- forming hydrophilic thickening agent is provided herein. The method includes the steps of evacuating gas from the dispersion and subjecting the degassed dispersion to compression by means of a relative pressure sufficient irreversibly to transform the dispersion into a stable particle-matrix system. A method of preparing a stable semi-solid preparation of dry, preferably bead-shaped water-absorbent particles of organic origin is also provided herein. Such method includes forming a homogenous dispersion comprising from 30 to 70% by weight of those bead- shaped, water-absorbent particles of organic origin, from 0.1% by weight of at least one hydrophilic thickening agent, capable of forming a matrix for such bead-shaped water-absorbent particles, and from 20 to 55% by weight of water, and stabilizing the dis- persion formed as above described. The water-absorbent particles of organic origin may consist of cross-linked carbohydrates or polyacrylamides or derivatives thereof. The stable preparation may advantageously be packed in aerosol-type containers and may be used for the treatment of wounds and skin.

509563

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