Method of producing active immunity with vaccine conjugate

A - Human Necessities – 61 – K

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A61K 39/40 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2264810

A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacterial or protozoa and a neutralizing factor bound to the live bacterial or protozoa. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live bacterial or protozoa is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live bacteria or protozoa.

Procédé servant à produire une immunité active contre une maladie provoquée par une bactérie ou par un protozoaire et consistant à administrer à un sujet un conjugué de vaccin contenant une bactérie ou un protozoaire vivants et un facteur neutralisant fixé à cette bactérie ou à ce protozoaire vivants. Ce facteur neutralisant est sélectionné dans le groupe constitué par des anticorps et des fragments d'anticorps. La bactérie ou le protozoaire vivants sont d'une espèce capable de provoquer une maladie chez le sujet et l'anticorps ou les fragments d'anticorps sont d'un type capable de neutraliser la bactérie ou le protozoaire vivants.

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