Method of producing aminophenyl ether compound

Details Method of producing aminophenyl ether compound Method of producing aminophenyl ether compound

C - Chemistry, Metallurgy

07

D

260/293, 260/547

C07D 295/096 (2006.01) C07D 213/82 (2006.01)

Patent

CA 1110248

SPECIFICATION TITLE OF THE INVENTION "METHOD OF PRODUCING AMINOPHENYL ETHER COMPOUNDS" ABSTRACT OF THE DISCLOSURE Method of producing aminophenyl ether compounds or the pharmacologically acceptable salts thereof having the formula Image wherein X1 represents hydrogen atom or a lower alkyl group; R2 represents a cyclohexyl group which may have been substituted by lower alkyl group(s), an alkyl group containing from 1 to 20 carbon atoms, a phenyl group or a benzyl group; R3 represents hydrogen atom, a lower alkyl group, or a cyclohexyl group which may have been substituted by lower alkyl group(s); R4 represents hydrogen atom, a lower alkyl group or a lower alkoxycarbonyl group; and R5 represents hydrogen atom, an aryl group or the group shown by -COR6 or -CH2R6 (wherein R6 represents hydrogen atom, an amino group, an alkyl group containing from 1 to 19 carbon atoms, a cyclohexyl group an aryl group, an aralkyl group, an aralkenyl group, an amino group substituted by lower alkyl group(s), a heterocyclic group which may have been substituted by lower alkyl group, or a bridged hydrocarbon group;) said R2 and R3 may, however, form together with the adjacent carbon atom a cyclohexane ring which may have been substituted by lower alkyl group(s) and said R4 and R5 may from together with the adjacent nitrogen atom a pyrrolidine ring or a piperidine ring. The above compounds have a hypolipemic activity, a cholesterol and a triglyceride reducing activity, and an activity of increasing high density lipoprotein (HDL) cholesterol, selectively.

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