Method of producing antibodies with modified fucosylation level

Details Method of producing antibodies with modified fucosylation level Method of producing antibodies with modified fucosylation level

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2608818

The invention provides methods for controlling fucosylation levels and improving ADCC activity in antibodies, by inhibiding the expression of FUT8 in antibody-producing cells.

L'invention concerne des méthodes destinées à réguler les taux de fucosylation et à renforcer l'activité ADCC dans des anticorps.

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