Method of producing antihypercholesterolemic agents

Details Method of producing antihypercholesterolemic agents Method of producing antihypercholesterolemic agents

C - Chemistry, Metallurgy

12

N

C12N 15/81 (2006.01) C12N 15/52 (2006.01) C12P 7/42 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2354736

A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wherein the segment is translated and where an increase in lovastatin production occurs.

L'invention concerne une méthode permettant d'augmenter la production de lovastatine ou de monacoline J dans un organisme produisant ou non de la lovastatine. Dans un mode de réalisation, cette méthode consiste notamment à transformer un organisme présentant le segment A. terreus D4B, ce segment étant traduit et la production de lovastatine augmentant.

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