Method of producing .gamma.-globulin for intravenous...

Details Method of producing .gamma.-globulin for intravenous... Method of producing .gamma.-globulin for intravenous...

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1181008

ABSTRACT OF THE DISCLOSURE A method is disclosed for producing ?-globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating ?-globulin with pepsin or uropepsin in a neutral pH range of 6.0 to 7.5. The aggregates in ?-globulin are selectively decomposed by the method of the present invention, while any decomposition of monomer ?-globulin molecule is substantially prevented. A therapeutic agent is also disclosed for intra- venous injection which has reduced anticomplementary activity and is stabilized by uropepsin which serves simultaneously as a proteolytic enzyme and a stabilizer. Uropepsinogen, pepsin or pepsinogen can also be used as a stabilizer.

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