C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/19 (2006.01) C07K 14/575 (2006.01) C07K 14/605 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2258307
The present invention relates to a novel method for the production of short chain polypeptides, including polypeptides having up to 3 disulfide bonds and/or structures rich in basic amino acid residues, and open structured short chain polypeptides, e.g. glucagon, glucagon like peptides and their functional analogues, in genetically modified yeast cells having reduced activity of YAP3 protease. The invention further comprises genetically modified yeast cells, and a method for the preparation of said yeast cells.
L'invention concerne un nouveau procédé de fabrication pour polypeptides à courte chaîne, y compris les polypeptides ayant jusqu'à 3 ponts disulfure et/ou des structures riches en résidus d'acides aminés de base, et aussi pour polypeptides à courte chaîne en structure ouverte (par exemple, glucagon, peptides du type glucagon et leurs analogues fonctionnels), dans des cellules de levure modifiées génétiquement ayant une activité réduite en protéase YAP3. On décrit les cellules de levure en question et un procédé pour leur élaboration.
Brandt Jakob
Egel-Mitani Michi
Vad Knud
Mccarthy Tetrault Llp
Novo Nordisk A/s
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