Method of producing igf-i and igfbp-3 with correct folding...

Details Method of producing igf-i and igfbp-3 with correct folding... Method of producing igf-i and igfbp-3 with correct folding...

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) C07K 1/113 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2223495

The present invention provides a novel method for refolding insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3). The method involves mixing of IGF-I and IGFBP-3 together in a cofolding reaction. The inventive cofolding method results in substantially higher yields of correctly folded protein for both molecules and alters the kinetics of refolding. The method includes the production of correctly folded IGF-I, IGFBP-3, and/or IGF-I/IGFBP-3 complex.

La présente invention se rapporte à un nouveau procédé de repliement du facteur de croissance insulinoïde I (IGF-I) et d'une protéine de liaison du facteur de croissance insulinoïde 3 (IGFBP-3). Le procédé consiste à mélanger IGF-I et IGFBP-3 au cours d'une réaction de corepliement. Le procédé de corepliement de l'invention donne lieu à des rendements sensiblement supérieurs de la protéine correctement pliée pour les deux molécules et modifie la cinétique du repliement. Le procédé comprend la production d'IGF-I, d'IGFBP-3 et/ou du complexe IGF-I/IGFBP-3 correctement pliés.

Affiliated with

Also associated with

Rating

Method of producing igf-i and igfbp-3 with correct folding... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of producing igf-i and igfbp-3 with correct folding..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing igf-i and igfbp-3 with correct folding... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1519737