Method of producing l-lysine

C - Chemistry – Metallurgy – 12 – N

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C12N 15/52 (2006.01) C12N 1/21 (2006.01) C12N 9/06 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/77 (2006.01) C12P 13/08 (2006.01)

Patent

CA 2224058

The L-lysine-producing ability and the L-lysine--producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihydrodipicolinate reductase, DNA coding for a dihydrodipicolinate synthase, DNA coding for a diaminopimelate decarboxylase, and DNA coding for a diaminopimelate dehydrogenase.

On améliore la production et la vitesse de production de L-Lysine en alimentant au moyen de corynebacteries l'aspartokinase, dans laquelle la rétro-inhibition produite par L-lysine et L-thréonine a été sensiblement réduite, et en activant successivement un ADN codant la dihydrodipicolinate réductase, un ADN codant la dihydrodipicolinate synthétase, un ADN codant la diaminopimelate décarboxylase et un ADN codant la diaminopimelate déshydrogénase.

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