Method of producing liposomes containing gas enclosed therein

Details Method of producing liposomes containing gas enclosed therein Method of producing liposomes containing gas enclosed therein

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 41/00 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2609373

It is intended to provide liposomes containing a gas enclosed therein which are useful in ultrasonic diagnostics and ultrasonic therapies. A method of producing liposomes containing a gas enclosed therein characterized by comprising filling the space in a sealed container, which contains a liposome suspension in a volume amounting to 20 to 80% of the inner capacity thereof, with a fluoride gas or a nitrogen gas and then conducting an ultrasonic treatment.

La présente invention concerne des liposomes renfermant un gaz, lesquels sont utiles dans le cadre des diagnostics et thérapies par ultrasons. L'invention décrit un procédé de production de liposomes renfermant un gaz, ledit procédé étant caractérisé en ce qu'il implique de remplir l'espace d'un récipient hermétiquement clos, contenant une suspension de liposomes en un volume représentant 20 à 80 % de sa capacité intérieure, avec du gaz fluoré ou azoté, puis d'exécuter un traitement par les ultrasons.

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