Method of producing macrolide compound

Details Method of producing macrolide compound Method of producing macrolide compound

C - Chemistry, Metallurgy

12

P

C12P 17/16 (2006.01) A61K 31/336 (2006.01) A61P 35/00 (2006.01) C07D 407/06 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2507641

It is intended to provide a novel process for producing a 12-membered macrolide compound 11107D having an antitumor activity via biological conversion. The 12-membered macrolide compound 11107B represented by the formula (I), which is a starting substance, is incubated in the presence of a strain capable of converting it into the compound 11107D represented by the formula (II) and belonging to the genus Mortierella or Streptomyces or the family of Micromonosporaceae(for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)) or a cultured cell preparation thereof together with oxygen and then the target compound 11107D is harvested from the incubation medium.

L'invention concerne un nouveau procédé de production d'un composé macrolide 11107D à 12 chaînons, doté d'une activité antitumorale, via transformation biologique. Le composé macrolide 11107B à 12 chaînons, représenté par la formule (I), qui est une substance de départ, est incubé en présence d'une souche capable de le transformer en composé 11107D, représenté par la formule (II), et appartenant au genre Mortierella ou Streptomyces ou à la famille de Micromonosporaceae (par exemple, souche de Streptomyces sp.AB-1704 (FERM BP-8551)), ou bien en une préparation cellulaire cultivée de celui-ci, conjointement avec de l'oxygène, après quoi le composé cible 11107D est récolté à partir du milieu d'incubation.

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