Method of producing multi-layer medicaments in solid form...

Details Method of producing multi-layer medicaments in solid form... Method of producing multi-layer medicaments in solid form...

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61J 3/10 (2006.01) A61K 9/02 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/07 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/4422 (2006.01) A61K 31/455 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/60 (2006.01)

Patent

CA 2232356

The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.

L'invention concerne un procédé de préparation de formes galéniques solides multicouches, pour administration orale ou rectale. Selon ce procédé, au moins deux matières qui contiennent chacune un liant polymère thermoplastique, pharmacologiquement acceptable, et soluble ou pouvant gonfler dans un environnement physiologique, et dont au moins une contient un principe actif pharmaceutique, sont coextrudées. Le matériau multicouche coextrudé est ensuite moulé pour prendre la forme galénique voulue.

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