Method of producing phospholipid derivatives

Details Method of producing phospholipid derivatives Method of producing phospholipid derivatives

C - Chemistry, Metallurgy

12

P

195/86

C12P 9/00 (2006.01) C07F 9/10 (2006.01)

Patent

CA 1283075

ABSTRACT A method of producing a new phospholipid derivative having two phosphatidyl residues from a starting material phospholipid derivative by transphosphatidylation. In this method, a phospholipid derivative (I) represented by the formula ... (I) Image is reacted with a chain polyhydric alcohol represented by the formula Image ... (II) in the presence of a phospholipase D having a transphosphatidylation activity (EC 3.1.4.4), thereby extracting a phospholipid derivative represented by the following formula from the reaction mixture Image ... (III) In the formulas, R1 and R2 represent acyl groups or alkyl groups, R3 represents an alkylene group (proviso, hydrogen atom may be substituted with a hydroxyl group, an alkoxyl group, a hydroxyalkyl group or the like), and X represents the organic residue remaining after the removal of one hydroxyl group of a compound containing hydroxyl group.

564062

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