Method of producing proanthocyanidin oligomer

Details Method of producing proanthocyanidin oligomer Method of producing proanthocyanidin oligomer

C - Chemistry, Metallurgy

07

D

C07D 311/62 (2006.01) A61K 8/00 (2006.01) A61K 31/353 (2006.01) A61K 36/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 39/06 (2006.01) A61P 43/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2599295

A composition containing, as the main component, a proanthocyanidin oligomer which is obtained by heating a plant material containing a proanthocyanidin polymer or its extract together with a substance having a phloroglucinol ring or resorcinol ring structure in an acidic solution, carries the substance having the fluoro/resorcinol ring structure attached thereto and has been degraded; a method of producing the same; and use of the composition in health foods, drugs and so on. Thus, the proanthocyanidin oligomer having a biological activity, carrying the substance having a phloroglucinol ring or resorcinol ring structure attached to the terminus thereof and having been degraded to a level allowing the absorption in vivo, which can be hardly obtained from a plant material at a high yield, can be efficiently and easily obtained.

La présente invention concerne une composition contenant, en tant que composant principal, un oligomère de proanthocyanidine que l~on obtient en chauffant un matériau végétal contenant un polymère de proanthocyanidine ou son extrait conjointement avec une substance ayant une structure à cycle phloroglucinol ou à cycle résorcinol dans une solution acide, qui porte la substance ayant la structure à cycle fluoro/résorcinol attachée à celle-ci et qui a été dégradée. La présente invention concerne également un procédé pour la fabriquer ; et l~utilisation de la composition dans des aliments pour la santé, des médicaments, et ainsi de suite. Ainsi, l~oligomère de proanthocyanidine ayant une activité biologique, portant la substance ayant une structure à cycle phloroglucinol ou à cycle résorcinol attachée à l~extrémité de celle-ci et ayant été dégradée à un niveau permettant l~absorption in vivo, que l~on peut difficilement obtenir à partir d~un matériau végétal à un rendement élevé, peut être obtenu efficacement et facilement.

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