Method of producing pyrrolidine derivatives

Details Method of producing pyrrolidine derivatives Method of producing pyrrolidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 207/20 (2006.01) C07D 207/46 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01)

Patent

CA 2281393

A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.

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