C - Chemistry – Metallurgy – 22 – B
Patent
C - Chemistry, Metallurgy
22
B
53/341
C22B 60/00 (2006.01) C01G 99/00 (2010.01) G21G 1/04 (2006.01)
Patent
CA 1113257
ABSTRACT The invention relates generally to a method for producing radioactive isotopes. More specifically, the invention relates to an improved chromatographic extraction method whereby Technetium-99m of high yield and high purity is produced. Technetium-99m which has a half life of six hours, is produced by the spontaneous radioactive decay of Molybdenum-99, which has a half life of 67 hours. The user then separates the desired amount of Technetium-99m from the Molyb- denum-99 as his needs require. Prior art separation methods are either non-specific or relatively inef- ficient. Additionally, with most of the prior art methods, Technetium-99m is produced in the form of an aqueous solvent whereas production in a solventless, i.e. dry particulate form, would be more desirable for purposes of flexibility in the preparation of diagnos- tic reagents of desired radioactive concentration. According to the present invention, Technetium-99m is produced in a dry particulate form of high yield and high purity. The method of the present invention com- prises the steps of eluting an adsorbant chromato- graphic material containing Molybdenum-99 and Techne- tium-99m with a neutral solvent system comprising an organic solvent containing from about 0.1 to less than about 10% water or from about 1 to less than about 70% of a solvent selected from the group consisting of aliphatic alcohols having 1-6 carbon atoms and separating the solvent system from the eluate whereby a dry, particulate residue is obtained containing Technetium-99m, said residue being substantially free of Molybdenum-99.
322216
Gowling Lafleur Henderson Llp
Karageozian Hampar L.
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