Method of producing reconstituted lipoproteins

Details Method of producing reconstituted lipoproteins Method of producing reconstituted lipoproteins

C - Chemistry, Metallurgy

07

K

C07K 14/775 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 38/17 (2006.01) A61K 47/26 (2006.01) C07K 1/113 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2138925

Reconstituted high density lipoproteins (rHDL) are produced from apolipoproteins and lipids in that an aqueous apolipoprotein solution with a concentration of 1 - 40 g protein/l is mixed with an aqueous lipid-detergent solution without mandatory addition of organic solvents, the molar ratio of lipid to detergent being 1: 0.5 to 1: 4 and the weight ratio of lipid to detergent being 1: 1.5 to 1: 5, the resultant apolipoprotein-lipid-detergent mixture then being incubated at a temperature in the range of the phase change temperature of the lipid in water ~ 10°C, and the detergent being at least partially removed. The rHDL are useful for various prophylactic and therapeutic treatments of diseases that have a connection with lipids and lipidoidal substances. This method is especially suitable for technical and industrial production.

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