Method of producing sub-micron particles of biologically...

Details Method of producing sub-micron particles of biologically... Method of producing sub-micron particles of biologically...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2388653

Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen droplets to obtain microstructures capable of being further fragmented into submicron particles by techniques such as probe sonication. The submicron particles can be incorporated into sustained release compositions having a reduced initial release of biologically active agent. The sustained release compositions can be administered to a human or animal.

L'invention porte sur des particules submicroniques d'un agent bioactif, qu'on prépare par pulvérisation d'un système multifluides à jet diffusé contenant au moins un agent bioactif et au moins un solvant destinés à produire des gouttelettes; par refroidissement des gouttelettes afin de produire des gouttelettes congelées; par lyophilisation des gouttelettes congelées afin d'obtenir des microstructures pouvant être refragmentées en particules submicroniques par des techniques telles que la sonication par sonde. Les particules submicroniques peuvent être incorporées dans des compositions à libération lente présentant une libération initiale réduite de l'agent bioactif, lesquelles compositions à libération lente peuvent être administrées à un humain ou à un animal.

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