Method of producing sustained-release microcapsules

Details Method of producing sustained-release microcapsules Method of producing sustained-release microcapsules

A - Human Necessities

61

K

A61K 9/58 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/06 (2006.01) A61K 38/09 (2006.01) A61K 38/21 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2105374

A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing the biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of the biologically active substance with the biodegradable polymer are heated at a temperature not lower than the glass transition temperature of the biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

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