Method of producing the a-30912 antibiotics

Details Method of producing the a-30912 antibiotics Method of producing the a-30912 antibiotics

C - Chemistry, Metallurgy

12

P

195/89, 530/15.0

C12P 17/18 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1154695

Abstract This invention relates to the process of producing the A-42355 antibiotic mixture comprising A-30912 factors A, B, D, and H and the individual factors, A-30912 factor A, A-30912 factor B, A-30912 factor D and A-30912 factor H which comprises cultivat- ing the newly isolated Aspergillus nitdulans var. roseus NRRL 11440 in a culture medium containing assimilable sources of carbohydrate, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced, separating the antibiotic mixture from the culture medium, and if desired, isolating the individual factors from the antibiotic mixture.

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