Method of production of sustained-release preparation

Details Method of production of sustained-release preparation Method of production of sustained-release preparation

A - Human Necessities

61

K

A61K 9/58 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/09 (2006.01) A61K 38/24 (2006.01)

Patent

CA 2184654

A method of production of sustained-release microcapsules that comprises obtaining microcapsules comprising a bioactive substance that are encapsulated with a biodegradable polymer, and thermally drying the obtained microcapsules at a temperature not lower than the glass transition temperature of the biodegradable polymer for about 24 to about 120 hours to produce the sustained- release microcapsules comprising, relative to the weight of the sustaind-release microcapsule, not less than 60% (w/w) of the biodegradable polymer, possessing pharmaceutical characteristics clinically excellent in that a bioactive substance is released at constant rate over a very long period of time from just after administration with dramatically suppressed initial release of the bioactive substance in excess just after administration and with minimum remaining organic solvent.

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