Method of prognosis in chronic kidney disease

Details Method of prognosis in chronic kidney disease Method of prognosis in chronic kidney disease

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2740632

The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (CKD), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytokine-1 (MIC- 1) in a test body sample from the diseased subject. A method of preventing or reducing the risk of death in a CKD subject which involves removing or inactivating MIC-1 present in the blood, plasma or serum of the subject, is also disclosed.

La présente invention concerne des procédés qui permettent de pronostiquer les chances de survie d'un sujet malade, en particulier dun sujet atteint d'une insuffisance rénale chronique et de sélectionner un sujet atteint d'une maladie rénale au stade terminal en vue d'une greffe rénale. Les procédés impliquent la détection d'une quantité élevée de cytokine-1 inhibitrice des macrophages (MIC-1) dans un prélèvement corporel d'essai du sujet malade. L'invention concerne aussi un procédé permettant de prévenir ou de réduire le risque de décès chez un sujet atteint d'une insuffisance rénale chronique, qui consiste à éliminer ou à inactiver les MIC-1 présents dans le sang, le plasma ou le sérum du sujet.

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