Method of proliferating lak cell

A - Human Necessities – 61 – K

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A61K 35/14 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2659697

Methods of therapy effective for various cancers, immune deficiency diseases and infections, and methods of proliferation/activation of cells associated therewith, performed at costs such as those applicable to nonhuman animals. There is provided a method of proliferation/activation, comprising, in the stage of cell culture, adding a plant lectin, such as concanavalin A, and a growth factor having interleukin 2-like activity to the medium. Accordingly, .alpha..beta.-type T cells associated with cellular immune for cancers, immune deficiency diseases and infections can be proliferated/activated on a preferential basis.

La présente invention concerne des procédés de thérapie efficaces pour le traitement de divers cancers, maladies résultant d'une déficience immunitaire et infections, ainsi que des procédés de prolifération/ d'activation de cellules associées à ces affections, accomplis à des coûts tels qu'ils sont pratiqués pour des animaux non humains. L'invention concerne un procédé de prolifération/ d'activation, consistant, au stade de la culture cellulaire, à ajouter au milieu une lectine végétale, telle que la concanavaline A, et un facteur de croissance présentant une activité de type interleukine 2. Il est par conséquent possible de faire proliférer/ d'activer des lymphocytes T de type .alpha..beta., associés à une réponse cellulaire immune contre les cancers, les maladies résultant d'une déficience immunitaire et les infections, sur une base préférentielle.

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