Method of promoting cervical and vaginal secretions

Details Method of promoting cervical and vaginal secretions Method of promoting cervical and vaginal secretions

A - Human Necessities

61

K

A61K 31/7072 (2006.01) A61K 31/00 (2006.01) A61K 31/7068 (2006.01) A61K 31/7076 (2006.01) A61K 31/7084 (2006.01) A61P 15/02 (2006.01)

Patent

CA 2352262

The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y2, and/or P2Y4 purinergic receptor agonists. Treatment of vaginal dryness associated with menopause, chemotherapy, and various disease states as well as the treatment of vulvar pain is discussed. Suitable purinergic receptor agonists include nucleotide triphosphates such as uridine 5-triphosphate, cytidine 5'-triphosphate and adenosine 5'-triphosphate; dinucleotide polyphosphates such as P1, P4- di(uridine-5') tetraphosphate; and their analogs. These purinergic receptor agonists are useful in stimulating cervical and vaginal secretions and treating vaginal dryness in mammals.

La présente invention concerne une méthode qui permet de stimuler les sécrétions cervicales et vaginales chez un mammifère. Cette méthode consiste à administrer un traitement faisant intervenir des agonistes des récepteurs purinergiques P2Y¿2? et/ou P2Y¿4?. L'invention porte sur le traitement de la sécheresse vaginale en rapport avec la ménopause, une chimiothérapie, divers états pathologiques. Ainsi que sur le traitement des douleurs vulvaires. Parmi des agonistes de récepteurs purinergiques appropriés figurent des triphosphates nucléotidiques tels qu'uridine 5-triphosphate, cytidine 5'-triphosphate et adénosine 5'-triphosphate; des polyphosphates dinucleotidiques tels que P?1¿, P?4¿-di(uridine-5') tétraphosphate; et leurs analogues. Les agonistes des récepteurs purinergiques permettent de stimuler les sécrétions cervicales et vaginales et de traiter la sécheresse vaginale chez les mammifères.

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