Method of promoting embryonic stem cell proliferation

Details Method of promoting embryonic stem cell proliferation Method of promoting embryonic stem cell proliferation

A - Human Necessities

61

K

A61K 38/08 (2006.01) C07K 7/14 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2320404

The present invention provides methods, improved cell culture medium and kits for promoting embryonic stem cell proliferation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof, or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.

L'invention concerne des méthodes, des milieux de culture cellulaire et des kits améliorés, destinés à favoriser la prolifération de cellules souches embryonnaires par une croissance en présence d'un angiotensinogène, de l'angiotensine I (AI), d'analogues de l'AI, de fragments de l'AI, et d'analogues de celle-ci, de l'angiotensine II (AII), d'analogues de l'AII, de fragments de l'AII, ou d'analogues de celle-ci, ou des agonistes du récepteur de l'AII AT¿2? de type 2, qu'ils soient utilisés seuls ou en combinaison avec d'autres facteurs de croissance et d'autres cytokines.

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