Method of promoting erythropoiesis

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) C07K 7/14 (2006.01)

Patent

CA 2319701

The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.

L'invention concerne des procédés, des composés, des compositions pharmaceutiques et des kits pour l'augmentation de l'érythropoïèse en potentialisant la différenciation induite par l'érythropoïétine avec l'angiotensinogène, l'angiotensine I (AI), des analogues de l'AI, des fragments d'AI et des analogues de ceux-ci, des analogues d'angiotensine II, des fragments d'AII ou des analogues de ceux-ci ou des agonistes récepteurs d'AII AT2 de type 2 utilisés comme appoint thérapeutique. Le procédé est utilisé pour le traitement d'anémies aplastiques ou hypoplastiques congénitales ou acquises associées à des insuffisances rénales chroniques, des affections rénales au stade final, des transplantation rénales, ainsi que pour le traitement du cancer, du SIDA, en chimiothérapie, radiothérapie, transplantation de moelle osseuse et le traitement de maladies chroniques.

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